Comparative Effectiveness and Outcomes Research

Infectious Diseases Research

Untitled Document

Professor Bruce R. Schackman, Ph.D. has had a longstanding commitment to HIV and hepatitis C testing and treatment research, including cost and cost-effectiveness analyses conducted alongside clinical trials and cohort studies; simulation modeling of comparative effectiveness and cost-effectiveness outcomes; and implementation science research regarding budgetary and operational barriers to implementing evidence-based medical interventions. Dr. Schackman is the director of the NIDA-funded Center for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIV (CHERISH). He has also collaborated with Cornell investigators in Haiti in exploring cost-effective methods for diagnosing and treating HIV and syphilis.

Dr. Schackman has an ongoing collaboration with the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) modeling group based at Massachusetts General Hospital in Boston. Working with this group, he has led or co-led studies of the lifetime cost of HIV care in the United States, the cost-effectiveness of using generic antiretroviral drugs for HIV treatment, and the cost-effectiveness of pharmacogenetic testing to guide HIV treatment selection. Dr. Schackman has also co-authored policy analyses and reviews related to HIV testing and treatment published in The New England Journal of Medicine, Health Affairs, Public Administration Review, and Medical Decision Making.

With funding from the National Institute on Drug Abuse (NIDA), Dr. Schackman has led economic studies conducted alongside randomized clinical trials of on-site rapid HIV testing in substance use treatment programs and sexually transmitted disease clinics, and is conducting ongoing economic research of the cost-effectiveness and budget impact of HIV and HCV testing and linkage to care in substance use treatment settings. He is collaborating with investigators in New York, Miami, and Puerto Rico on NIDA-funded studies of interventions to enhance HIV care for substance users in San Juan, Puerto Rico and HCV care for injection drug users in Bronx, New York. Dr. Schackman’s research team is also collaborating with the New York City Department of Health and Mental Hygiene on evaluating Project INSPIRE, a comprehensive services model for HCV-centered care that is supported by the Centers for Medicare and Medicaid Services.

Dr. Schackman has collaborated with the Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) in Haiti to conduct an economic evaluation a new rapid syphilis test for pregnant women; to conduct a cost-effectiveness analysis alongside a the only published randomized trial of early versus standard HIV treatment; and to forecast lives saved by expanding HIV treatment availability in Haiti. Dr. Schackman’s research collaborators in Haiti including Jean W. Pape, M.D., founder and director of GHESKIO and Professor of Medicine, Warren D. Johnson, M.D., the B.H. Kean Professor of Tropical Medicine, and Daniel W. Fitzgerald, M.D., Associate Professor of Medicine.

Mathew S. Simon, M.D. M.S., Associate Hospital Epidemiologist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center and Assistant Professor of Medicine and of Healthcare Policy & Research at Weill Cornell Medical College. He has recently published on the public health impact of a recent outbreak of invasive meningococcal disease in New York City in collaboration with the New York City Department of Health and Mental Hygiene, and has evaluated the cost-effectiveness of screening the blood supply for babesiosis in endemic regions.


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